| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
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| Ligand | BDBM639349 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | >20000±n/a nM |
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| Citation |  Beck, H; Mesch, S; Vakalopoulos, A; Pfaff, N; Zimmermann, S; Follmann, M; Kersten, E; Levilain, G; Partikel, K; Broehl, AP; Heitmeier, S; Dietze-Torres, J; Lehmann, L; Gericke, KM; Süßmeier, F; Bärfacker, L; Hillisch, A; Tersteegen, A; Buchmüller, A; Gerdes, C SUBSTITUTED S-ALANINATE DERIVATIVES US Patent US20230391761 Publication Date 12/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C8 |
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| Name: | Cytochrome P450 2C8 |
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| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 55839.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10632 |
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| Residue: | 490 |
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| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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| BDBM639349 |
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| n/a |
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| Name | BDBM639349 |
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| Synonyms: | 2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{2-ethyl-3-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]benzene-1-sulfonyl}-S-alaninate | US20230391761, Example 1 | US20230391761, Example 2 | US20230391761, Example 3 | US20230391761, Example 5 | US20230391761, Example 6 | US20230391761, Example 7 | US20230391761, Example 8 | US20230391761, Example 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30ClN5O7S2 |
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| Mol. Mass. | 624.129 |
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| SMILES | CCc1c(cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)OCCc1nccn1C)N1CC[C@H](O)C1=O |r| |
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| Structure | 
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