| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
|---|
| Ligand | BDBM644446 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay for Inhibitors of CLK2 Kinase Activity Assay |
|---|
| IC50 | 507±n/a nM |
|---|
| Citation |  Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof US Patent US11866436 Publication Date 1/9/2024 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK2 |
|---|
| Name: | Dual specificity protein kinase CLK2 |
|---|
| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 60128.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49760 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
|
|
|
|---|
| BDBM644446 |
|---|
| n/a |
|---|
| Name | BDBM644446 |
|---|
| Synonyms: | 5-((2-(4-((3-Chloro-5-(cyanomethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide | US11866436, Example 40 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29ClN6O2 |
|---|
| Mol. Mass. | 517.022 |
|---|
| SMILES | NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 |
|---|
| Structure | 
|
|---|
Search and Browse
