| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM656633 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Menin-MLL Competition Assay |
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| IC50 | <100±n/a nM |
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| Citation |  McGeehan, GM; Miller, WH; Camp, NP; Cacatian, S; Kulkarni, SS; Samanta, SK; Reddy, VV Inhibitors of the menin-MLL interaction US Patent US11919901 Publication Date 3/5/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM656633 |
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| n/a |
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| Name | BDBM656633 |
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| Synonyms: | N-((3R,6S)-6-((2-(5-(2-((3R,5R)-3,5- dimethylmorpholine-4-carbonyl)-4- fluorophenoxy)pyrimidin-4-yl)-2,7- diazaspiro[3.5]nonan-7-yl)methyl)tetrahydro-2H- pyran-3-yl)methanesulfonamide | US11919901, Compound 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H43FN6O6S |
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| Mol. Mass. | 646.773 |
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| SMILES | C[C@@H]1COC[C@@H](C)N1C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NS(C)(=O)=O)CC2 |r| |
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| Structure | 
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