| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM168253 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Mnk Biochemical Enzymatic Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >100±n/a nM |
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| Comments | extracted |
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| Citation |  Reich, SH; Sprengeler, PA; Webber, SE; Xiang, AX; Ernst, JT MNK inhibitors and methods related thereto US Patent US9669031 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
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| Type: | Protein |
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| Mol. Mass.: | 51870.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HBH9 |
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| Residue: | 465 |
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| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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| BDBM168253 |
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| n/a |
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| Name | BDBM168253 |
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| Synonyms: | US9669031, 81 8-methoxy-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 81) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15N5O3 |
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| Mol. Mass. | 301.3006 |
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| SMILES | COc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C |
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| Structure | 
|
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