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TargetGlycogen synthase kinase-3 beta
LigandBDBM314409
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
IC50 880±n/a nM
Citation Alisi, MA; Cazzolla, N; Dragone, P; Furlotti, G; Maugeri, C; Ombrato, R; Mancini, F 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors US Patent US9611249 Publication Date 4/4/2017
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM314409
n/a
NameBDBM314409
Synonyms:N-({1-[3-(but-2-ynoylamino)propyl] piperidin-4-yl}methyl)-5-methoxy-1H- indazole-3-carboxamide | US9611249, Compound 40
TypeSmall organic molecule
Emp. Form.C22H29N5O3
Mol. Mass.411.4974
SMILESCOc1ccc2[nH]nc(C(=O)NCC3CCN(CCCNC(=O)C#CC)CC3)c2c1
Structure
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