Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(1A) dopamine receptor | ||
| Ligand | BDBM200951 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Binding Assay | ||
| pH | 7.4±n/a | ||
| Ki | 1.9±0 nM | ||
| Comments | extracted | ||
| Citation |  Gray, DL; Zhang, L; Brodney, MA; Green, ME; Subramanyam, C Substituted 1,7-naphthyridines as dopamine D1 ligands US Patent US9540352 Publication Date 1/10/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(1A) dopamine receptor | |||
| Name: | D(1A) dopamine receptor | ||
| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49303.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21728 | ||
| Residue: | 446 | ||
| Sequence: |
| ||
| BDBM200951 | |||
| n/a | |||
| Name | BDBM200951 | ||
| Synonyms: | 6-[4-(isoquinolin-1-yloxy)-2-methylphenyl]-1,5-dimethylpyrimidine-2,4(1h,3h)-dione (5) | US9540352, example 5 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19N3O3 | ||
| Mol. Mass. | 373.4046 | ||
| SMILES | Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C |(-2.99,8.7,;-2.99,7.16,;-4.32,6.39,;-4.32,4.85,;-5.66,4.08,;-5.66,2.54,;-4.32,1.77,;-4.32,.23,;-5.66,-.54,;-6.99,.23,;-8.32,-.54,;-9.66,.23,;-9.66,1.77,;-8.32,2.54,;-6.99,1.77,;-2.99,4.08,;-1.65,4.85,;-1.65,6.39,;-.32,7.16,;-.32,8.7,;-1.65,9.47,;1.01,9.47,;1.01,11.01,;2.35,8.7,;2.35,7.16,;3.68,6.39,;1.01,6.39,;1.01,4.85,)| | ||
| Structure | 
| ||