| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM336540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF-Based Assay |
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| IC50 | 10.6±n/a nM |
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| Citation |  Ali, A; Lo, MM; Metzger, E; Yin, L; Hartmann, R; Hu, Q; Heim, R; Zimmer, C Indoline compounds as aldosterone synthase inhibitors US Patent US9745282 Publication Date 8/29/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM336540 |
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| n/a |
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| Name | BDBM336540 |
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| Synonyms: | 1-(7-chloro-5-(5- fluoropyridin-3- yl)indon-1-yl)- 2,2,2- trifluoroethanone | US9745282, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9ClF4N2O |
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| Mol. Mass. | 344.691 |
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| SMILES | Fc1cncc(c1)-c1cc2CCN(C(=O)C(F)(F)F)c2c(Cl)c1 |
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| Structure | 
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