| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM272552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP-FP assay |
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| IC50 | 0.800±n/a nM |
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| Citation |  Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Compounds that are ERK inhibitors US Patent US9745307 Publication Date 8/29/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
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| Type: | Ser/Thr Protein Kinase |
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| Mol. Mass.: | 41392.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 |
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| Residue: | 360 |
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| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM272552 |
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| n/a |
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| Name | BDBM272552 |
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| Synonyms: | US10065967, Example 18 | US10759805, Ex 18 | US9745307, Example 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N5O2 |
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| Mol. Mass. | 399.4451 |
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| SMILES | COc1ccccc1CN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |
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| Structure | 
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