Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Ligand | BDBM13952 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 24000±n/a nM |
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Kd | 26000±n/a nM |
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Comments | Kd derived from 15N-labeled PTP1B |
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Citation | Liu, G; Szczepankiewicz, BG; Pei, Z; Janowick, DA; Xin, Z; Hajduk, PJ; Abad-Zapatero, C; Liang, H; Hutchins, CW; Fesik, SW; Ballaron, SJ; Stashko, MA; Lubben, T; Mika, AK; Zinker, BA; Trevillyan, JM; Jirousek, MR Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem46:2093-103 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 34670.65 |
Organism: | Homo sapiens (Human) |
Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
Residue: | 298 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM13952 |
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BDBM13466 |
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Name | BDBM13952 |
Synonyms: | 2-(Naphthalen-1-yloxalylamino)benzoic Acid | 2-(naphthalen-1-ylamidoformic acid)benzoic acid | CHEMBL64934 | naphthyloxamic acid 5 |
Type | Small organic molecule |
Emp. Form. | C19H13NO5 |
Mol. Mass. | 335.3102 |
SMILES | OC(=O)C(=O)N(c1ccccc1C(O)=O)c1cccc2ccccc12 |
Structure |
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