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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287555 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Activity Assay | ||
| IC50 | 5.60±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9815834 Publication Date 11/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM287555 | |||
| n/a | |||
| Name | BDBM287555 | ||
| Synonyms: | 8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 103 | US11078199, Cpd 103 | US9567334, Example 103 | US9815834, Compound 103 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H40Cl2N6O5 | ||
| Mol. Mass. | 647.593 | ||
| SMILES | CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| | ||
| Structure | 
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