| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM359626 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KLK1 inhibitory activity |
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| IC50 | 14900±n/a nM |
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| Citation |  Edwards, HJ; Evans, DM; Meghani, P; Novak, AR Inhibitors of plasma kallikrein US Patent US10221161 Publication Date 3/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM359626 |
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| n/a |
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| Name | BDBM359626 |
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| Synonyms: | N-({2,4-Dimethyl-7H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-5-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl)pyridine-3-carboxamide | US10221161, Example 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N6O |
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| Mol. Mass. | 464.5615 |
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| SMILES | Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3c(C)nc4[nH]ccc(C)c34)cc2)c1 |
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| Structure | 
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