| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM19488 |
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| Substrate/Competitor | BDBM19480 |
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| Meas. Tech. | In Vitro Enzyme Assay |
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| pH | 6.1±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 9.6±2.4 nM |
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| Citation |  Inagaki, H; Tsuruoka, H; Hornsby, M; Lesley, SA; Spraggon, G; Ellman, JA Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. J Med Chem50:2693-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM19488 |
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| BDBM19480 |
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| Name | BDBM19488 |
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| Synonyms: | 2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenoxy}acetaldehyde | Aldehyde Inhibitor, 12e |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F2O2 |
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| Mol. Mass. | 304.3311 |
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| SMILES | CC(C)Cc1ccc(c(F)c1F)-c1ccccc1OCC=O |
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| Structure | 
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