Reaction Details |
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Target | Proteinase-activated receptor 4 |
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Ligand | BDBM364941 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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IC50 | 0.590±n/a nM |
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Citation | Lawrence, RM; Miller, MM; Seiffert, DA; Posy, SL; Wong, PC; Banville, J; Ruediger, EH; Deon, DH; Martel, A; Tremblay, F; Guy, J; Lavallée, J; Gagnon, M Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9862730 Publication Date 1/9/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Proteinase-activated receptor 4 |
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Name: | Proteinase-activated receptor 4 |
Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
Type: | Protein |
Mol. Mass.: | 41145.16 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI0 |
Residue: | 385 |
Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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BDBM364941 |
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n/a |
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Name | BDBM364941 |
Synonyms: | US9862730, Example 399 |
Type | Small organic molecule |
Emp. Form. | C26H22N4O5S2 |
Mol. Mass. | 534.607 |
SMILES | COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(OCc4csc(C)n4)c3)cc(OC)cc2o1 |
Structure |
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