| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 2 group C member 2 |
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| Ligand | BDBM375281 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 22.8±n/a nM |
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| Citation |  Treon, SP; Buhrlage, SJ; Gray, NS; Tan, L; Yang, G Methods to treat lymphoplasmacytic lymphoma US Patent US9908872 Publication Date 3/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 2 group C member 2 |
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| Name: | Nuclear receptor subfamily 2 group C member 2 |
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| Synonyms: | NR2C2 | NR2C2_HUMAN | Nuclear receptor subfamily 2 group C member 2 | Nuclear receptor subfamily 2 group C member 2 (TAK1) | TAK1 | TR4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65411.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476357 |
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| Residue: | 596 |
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| Sequence: | MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAG
TGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVC
GDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEM
GMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLL
DPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQ
PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGP
LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVR
ACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCN
SMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRL
ARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
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| BDBM375281 |
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| n/a |
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| Name | BDBM375281 |
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| Synonyms: | US10597387, Compound (I-4) | US9908872, Compound (I-4) |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28F3N5O2S |
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| Mol. Mass. | 579.636 |
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| SMILES | CN1CCN(CC1)c1cc(NC(=O)c2ccc(C)c(NC(=O)c3cncc(c3)-c3cccs3)c2)cc(c1)C(F)(F)F |
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| Structure | 
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