| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
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| Ligand | BDBM385389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SSAO/VAP-1 In Vitro Activity |
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| IC50 | 52.0±5 nM |
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| Citation |  Coates, DA; Qin, LH; Wei, Y; Zhou, J Amino pyrimidine SSAO inhibitors US Patent US10287270 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane primary amine oxidase |
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| Name: | Membrane primary amine oxidase |
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| Synonyms: | AOC3 | AOC3_HUMAN | Amine oxidase, copper containing | Semicarbazide-sensitive amine oxidase (SSAO) | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | VAP1 | Vascular adhesion protein 1 (VAP-1) |
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| Type: | Protein |
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| Mol. Mass.: | 84620.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16853 |
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| Residue: | 763 |
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| Sequence: | MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
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| BDBM385389 |
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| n/a |
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| Name | BDBM385389 |
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| Synonyms: | (3 S)-1-[5-[(E)-2-(Aminomethyl)-3-fluoro-allyloxy]pyrimidin-2-yl]pyrrolidin-3-ol; Dihydrochloride | US10287270, Example 6 | US10464928, Example 6 | US10793552, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17FN4O2 |
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| Mol. Mass. | 268.2874 |
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| SMILES | NC\C(COc1cnc(nc1)N1CC[C@H](O)C1)=C/F |r| |
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| Structure | 
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