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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 2 | ||
| Ligand | BDBM287517 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition of FGFR2-Dependent Cell Growth | ||
| IC50 | 5.00±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 2 | |||
| Name: | Fibroblast growth factor receptor 2 | ||
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92015.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21802 | ||
| Residue: | 821 | ||
| Sequence: |
| ||
| BDBM287517 | |||
| n/a | |||
| Name | BDBM287517 | ||
| Synonyms: | (S)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl)methyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 113 | US11078199, Cpd 113 | US9567334, Example 113 | US9815834, Compound 113 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H30Cl2N6O4 | ||
| Mol. Mass. | 573.471 | ||
| SMILES | CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1 |r,wU:24.24,(-6.67,-.86,;-6.67,.68,;-5.33,1.45,;-5.33,2.99,;-4,3.76,;-2.67,2.99,;-1.33,3.76,;,2.99,;1.33,3.76,;1.33,5.3,;,6.07,;2.67,6.07,;2.67,7.61,;4,8.38,;4,5.3,;4,3.76,;5.33,2.99,;6.67,3.76,;2.67,2.99,;2.67,1.45,;,1.45,;1.33,.68,;-1.33,.68,;-1.33,-.86,;-2.67,-1.63,;-4.13,-1.16,;-5.04,-2.4,;-4.13,-3.65,;-2.67,-3.17,;-1.58,-4.26,;-1.58,-5.8,;-.04,-5.8,;-.04,-4.26,;1.05,-6.89,;.65,-8.38,;2.54,-6.49,;3.63,-7.58,;-2.67,1.45,;-4,.68,)| | ||
| Structure | 
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