Ki Summary

Reaction Details

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Target

Fibroblast growth factor receptor 2

Ligand

BDBM287555

Substrate/Competitor

n/a

Meas. Tech.

Inhibition of FGFR2-Dependent Cell Growth

IC50

5.60±n/a nM

Citation

Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US10294223 Publication Date 5/21/2019

More Info.:

Get all data from this article, Assay Method

Fibroblast growth factor receptor 2

Name:

Fibroblast growth factor receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

92015.45

Organism:

Homo sapiens (Human)

Description:

P21802

Residue:

821

Sequence:

MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT

BDBM287555

n/a

Name

BDBM287555

Synonyms:

8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 103 | US11078199, Cpd 103 | US9567334, Example 103 | US9815834, Compound 103

Type

Small organic molecule

Emp. Form.

C31H40Cl2N6O5

Mol. Mass.

647.593

SMILES

CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)|

Structure