Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM29752 |
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Substrate/Competitor | Cathepsin D Peptide Substrate |
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Meas. Tech. | Enzyme Inhibition Measurements |
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pH | 3.1±n/a |
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Temperature | 295.15±n/a K |
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Comments | Not active. |
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Citation | Machauer, R; Veenstra, S; Rondeau, JM; Tintelnot-Blomley, M; Betschart, C; Neumann, U; Paganetti, P Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett19:1361-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM29752 |
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Cathepsin D Peptide Substrate |
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Name: | Cathepsin D Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2375.29 |
Organism: | n/a |
Description: | Peptide substrates were obtained from Bachem (Bubendorf, Switzerland). |
Residue: | 20 |
Sequence: | Mca-GKPILFFRLK(DNP)-D-R-NH2
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