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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM264152 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.20±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent US9714234 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM264152 | |||
| n/a | |||
| Name | BDBM264152 | ||
| Synonyms: | 4-(3-(S)-(8-Fluoro-1-methyl(d3)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-5-methyl-9H-carbazole-1-carboxamide (Mixture of Two diastereomers) | US9714234, 27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H29FN4O4 | ||
| Mol. Mass. | 564.6062 | ||
| SMILES | Cc1cc(cc2[nH]c3c(ccc(-c4cccc(c4C)-n4c(=O)n(C)c5c(F)cccc5c4=O)c3c12)C(N)=O)C(C)(C)O |(-3.01,-.34,;-3.01,1.2,;-4.54,1.04,;-5.44,2.28,;-4.82,3.69,;-3.29,3.85,;-2.38,5.1,;-.92,4.62,;.42,5.39,;1.75,4.62,;1.75,3.08,;.42,2.31,;.42,.77,;-.92,,;-.92,-1.54,;.42,-2.31,;1.75,-1.54,;1.75,,;3.08,.77,;3.08,-2.31,;3.08,-3.85,;1.75,-4.62,;4.42,-4.62,;4.42,-6.16,;5.75,-3.85,;7.09,-4.62,;7.09,-6.16,;8.42,-3.85,;8.42,-2.31,;7.09,-1.54,;5.75,-2.31,;4.42,-1.54,;4.42,,;-.92,3.08,;-2.38,2.6,;.42,6.93,;1.75,7.7,;-.92,7.7,;-6.93,1.88,;-7.33,.4,;-8.42,1.48,;-8.02,2.97,)| | ||
| Structure | 
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