| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM264779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P. aeruqinosa LpxC Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.001±n/a nM |
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| Comments | extracted |
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| Citation |  Fu, J; Jin, X; Karur, S; LaPointe, G; Lee, P; Sweeney, ZK Isoxazoline hydroxamic acid derivatives as LpxC inhibitors US Patent US9718792 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC |
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| Type: | Enzyme |
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| Mol. Mass.: | 33428.15 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | P47205 |
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| Residue: | 303 |
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| Sequence: | MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ
EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS
FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA
AAV
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| BDBM264779 |
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| n/a |
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| Name | BDBM264779 |
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| Synonyms: | US9718792, 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N2O5S |
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| Mol. Mass. | 354.421 |
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| SMILES | CCc1ccc(cc1)C1=NO[C@@H](C[C@](C)(C(=O)NO)S(C)(=O)=O)C1 |r,t:9| |
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| Structure | 
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