| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential M8 protein |
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| Ligand | BDBM241619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Canine TRPM8 Functional Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 3.50±n/a nM |
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| Comments | extracted |
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| Citation |  Player, MR; Calvo, R; Chen, J; Meegalla, S; Parks, DJ; Parsons, WJ; Ballentine, S; Branum, S Substituted aza-bicyclic imidazole derivatives useful TRPM8 receptor modulators US Patent US9718820 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential M8 protein |
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| Name: | Transient receptor potential M8 protein |
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| Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
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| Type: | Enzyme |
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| Mol. Mass.: | 127589.43 |
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| Organism: | Canis lupus familiaris (Dog) |
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| Description: | Q1A7N1 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
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| BDBM241619 |
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| n/a |
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| Name | BDBM241619 |
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| Synonyms: | US9409915, 11 | US9718820, Compound 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21Cl2N5O |
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| Mol. Mass. | 430.33 |
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| SMILES | COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl |
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| Structure | 
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