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Compile Data Set for Download or QSAR

Found 1768 hits with Last Name = 'meegalla' and Initial = 's'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50055824
PNG
(2-{[(2R,3S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bic...)
Show SMILES CN1C2CCC1[C@@H](CN(CCS)CCNCCS)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3|
Show InChI InChI=1S/C21H34ClN3S2/c1-24-18-6-7-21(24)20(15-25(11-13-27)10-8-23-9-12-26)19(14-18)16-2-4-17(22)5-3-16/h2-5,18-21,23,26-27H,6-15H2,1H3/t18?,19-,20+,21?/m1/s1
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 7n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro binding affinity to Dopamine transporter in rat striatal homogenates using [125I]-IPT20 as the ligand

J Med Chem 40: 9-17 (1997)


Article DOI: 10.1021/jm960532j
BindingDB Entry DOI: 10.7270/Q2WM1CHJ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50062680
PNG
(2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...)
Show SMILES CN1C2CCC1[C@@H]([C@@H]2CN1CCS[Re]2(=O)SCCN2CC1)c1ccc(Cl)cc1 |TLB:8:7:1:4.3,THB:21:6:1:4.3|
Show InChI InChI=1S/C20H31ClN3S2.O.Re/c1-23-18-6-7-19(23)20(15-2-4-16(21)5-3-15)17(18)14-24(11-13-26)10-8-22-9-12-25;;/h2-5,17-20,25-26H,6-14H2,1H3;;/q-1;;+4/p-2/t17-,18?,19?,20-;;/m1../s1
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 8.42n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligand

J Med Chem 41: 428-36 (1998)


Article DOI: 10.1021/jm970742b
BindingDB Entry DOI: 10.7270/Q2DN4459
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM50062679
PNG
(2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...)
Show SMILES CN1C2CCC1[C@@H]([C@H]2CN1CCS[Re]2(=O)SCCN2CC1)c1ccc(Cl)cc1 |TLB:8:7:1:4.3,THB:21:6:1:4.3|
Show InChI InChI=1S/C20H31ClN3S2.O.Re/c1-23-18-6-7-19(23)20(15-2-4-16(21)5-3-15)17(18)14-24(11-13-26)10-8-22-9-12-25;;/h2-5,17-20,25-26H,6-14H2,1H3;;/q-1;;+4/p-2/t17-,18?,19?,20+;;/m0../s1
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 13.9n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligand

J Med Chem 41: 428-36 (1998)


Article DOI: 10.1021/jm970742b
BindingDB Entry DOI: 10.7270/Q2DN4459
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50055825
PNG
(CHEMBL295441 | Rhenium Compound)
Show SMILES CN1C2CCC1[C@@H](CN1CCS[Re]3(=O)SCCN3CC1)[C@H](C2)c1ccc(Cl)cc1 |TLB:7:6:1:4.3|
Show InChI InChI=1S/C21H33ClN3S2.O.Re/c1-24-18-6-7-21(24)20(15-25(11-13-27)10-8-23-9-12-26)19(14-18)16-2-4-17(22)5-3-16;;/h2-5,18-21,26-27H,6-15H2,1H3;;/q-1;;+4/p-2/t18?,19-,20+,21?;;/m1../s1
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 14n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards dopamine transporter using [125I]-IPT20 as radioligand in rat striatal homogenates

J Med Chem 40: 9-17 (1997)


Article DOI: 10.1021/jm960532j
BindingDB Entry DOI: 10.7270/Q2WM1CHJ
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50335165
PNG
(3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...)
Show SMILES OCCCc1cc(cc2[nH]c(nc12)C1=NOC2(C1)CCCCC2)-c1ccccc1C(F)(F)F |t:15|
Show InChI InChI=1S/C25H26F3N3O2/c26-25(27,28)19-9-3-2-8-18(19)17-13-16(7-6-12-32)22-20(14-17)29-23(30-22)21-15-24(33-31-21)10-4-1-5-11-24/h2-3,8-9,13-14,32H,1,4-7,10-12,15H2,(H,29,30)
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay

J Med Chem 54: 233-47 (2011)


Article DOI: 10.1021/jm101075v
BindingDB Entry DOI: 10.7270/Q20C4WRJ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS

Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50321368
PNG
(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization

Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50377071
PNG
(CHEMBL402337)
Show SMILES CC1CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CCNCC1 |c:4|
Show InChI InChI=1S/C23H27N5O/c1-15-2-4-17(5-3-15)20-12-18(16-8-10-25-11-9-16)6-7-21(20)28-23(29)22-26-14-19(13-24)27-22/h4,6-7,12,14-16,25H,2-3,5,8-11H2,1H3,(H,26,27)(H,28,29)
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n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS

Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1


(Mus musculus (Mouse))		BDBM97732
PNG
(US8481564, 8)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
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n/an/a 0.400n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50321373
PNG
(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization

Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50335157
PNG
(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F |t:22|
Show InChI InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
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n/an/a 0.413n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiology

J Med Chem 54: 233-47 (2011)


Article DOI: 10.1021/jm101075v
BindingDB Entry DOI: 10.7270/Q20C4WRJ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1


(Mus musculus (Mouse))		BDBM97739
PNG
(US8481564, 54)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30,(-8.73,-1.92,;-7.39,-2.69,;-6.06,-1.93,;-4.73,-2.69,;-4.73,-4.23,;-6.06,-5,;-6.06,-6.54,;-7.39,-4.23,;-8.73,-5,;-8.73,-6.54,;-8.73,-8.08,;-3.39,-1.93,;-2.06,-2.69,;-.72,-1.93,;-.72,-.38,;.61,.38,;1.94,-.38,;1.94,-1.93,;3.28,.38,;3.28,1.93,;4.74,2.4,;5.65,1.15,;4.74,-.09,;5.51,3.73,;6.28,5.07,;-2.06,.38,;-3.39,-.38,;-2.06,1.93,;-.72,2.69,;-.72,4.23,;-2.06,5,;-3.15,6.09,;-.72,5.77,;-3.39,4.23,;-3.39,2.69,)|
Show InChI InChI=1S/C26H33N7O.C2HF3O2/c1-26(2)10-8-17(9-11-26)21-12-18(19-15-32(4)25(28-3)33(5)16-19)6-7-22(21)31-24(34)23-29-14-20(13-27)30-23;3-2(4,5)1(6)7/h6-8,12,14,19H,9-11,15-16H2,1-5H3,(H,29,30)(H,31,34);(H,6,7)/b28-25-;
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238106
PNG
(US9394289, 2)
Show SMILES CN(C)CCOC1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H37N5O3/c1-27(2)9-7-20(8-10-27)23-17-21(28(11-14-35-15-12-28)36-16-13-33(3)4)5-6-24(23)32-26(34)25-30-19-22(18-29)31-25/h5-7,17,19H,8-16H2,1-4H3,(H,30,31)(H,32,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.440n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238129
PNG
(US9394289, 25)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CO)CCOCC1 |c:5|
Show InChI InChI=1S/C25H30N4O3/c1-24(2)7-5-17(6-8-24)20-13-18(25(16-30)9-11-32-12-10-25)3-4-21(20)29-23(31)22-27-15-19(14-26)28-22/h3-5,13,15,30H,6-12,16H2,1-2H3,(H,27,28)(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50321365
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28|
Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization

Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50321367
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28|
Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization

Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238109
PNG
(US9394289, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(N)CCOCC1 |c:5|
Show InChI InChI=1S/C24H29N5O2/c1-23(2)7-5-16(6-8-23)19-13-17(24(26)9-11-31-12-10-24)3-4-20(19)29-22(30)21-27-15-18(14-25)28-21/h3-5,13,15H,6-12,26H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 0.5n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241685
PNG
(US9409915, 89 | US9718820, Compound 89)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C22H20Cl2F3N5O/c1-21(2,3)18-15(24)17(32(4)31-18)19-28-14-9-13(11-7-5-6-8-12(11)23)29-20(16(14)30-19)33-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,28,30)
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n/an/a 0.530n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...

US Patent US9718820 (2017)


BindingDB Entry DOI: 10.7270/Q2RV0QQ5
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241685
PNG
(US9409915, 89 | US9718820, Compound 89)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C22H20Cl2F3N5O/c1-21(2,3)18-15(24)17(32(4)31-18)19-28-14-9-13(11-7-5-6-8-12(11)23)29-20(16(14)30-19)33-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,28,30)
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n/an/a 0.530n/an/an/an/an/a37



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...

US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238121
PNG
(US9394289, 17)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCOCC1)C(O)=O |c:5|
Show InChI InChI=1S/C25H28N4O4/c1-24(2)7-5-16(6-8-24)19-13-17(25(23(31)32)9-11-33-12-10-25)3-4-20(19)29-22(30)21-27-15-18(14-26)28-21/h3-5,13,15H,6-12H2,1-2H3,(H,27,28)(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241633
PNG
(US9409915, 16 | US9718820, Compound 16)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O/c1-12(2)34-22-18-16(11-15(30-22)13-9-7-8-10-14(13)24(26,27)28)29-21(31-18)19-17(25)20(23(3,4)5)32-33(19)6/h7-12H,1-6H3,(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...

US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241633
PNG
(US9409915, 16 | US9718820, Compound 16)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O/c1-12(2)34-22-18-16(11-15(30-22)13-9-7-8-10-14(13)24(26,27)28)29-21(31-18)19-17(25)20(23(3,4)5)32-33(19)6/h7-12H,1-6H3,(H,29,31)
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n/an/a 0.590n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...

US Patent US9718820 (2017)


BindingDB Entry DOI: 10.7270/Q2RV0QQ5
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)

Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50335170
PNG
(3-[5-(2-Fluoro-6-trifluoromethylphenyl)-1H-benzimi...)
Show SMILES Fc1cccc(c1-c1ccc2nc([nH]c2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F |t:19|
Show InChI InChI=1S/C22H19F4N3O/c23-15-6-4-5-14(22(24,25)26)19(15)13-7-8-16-17(11-13)28-20(27-16)18-12-21(30-29-18)9-2-1-3-10-21/h4-8,11H,1-3,9-10,12H2,(H,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay

J Med Chem 54: 233-47 (2011)


Article DOI: 10.1021/jm101075v
BindingDB Entry DOI: 10.7270/Q20C4WRJ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)

Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50233716
PNG
(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)
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n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization

Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM193240
PNG
(US9193736, 164)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1 |wU:24.27,wD:26.32,(4.46,-12.1,;4.14,-10.59,;2.67,-10.12,;5.28,-9.56,;4.96,-8.06,;6.11,-7.03,;7.57,-7.5,;7.89,-9.01,;6.75,-10.04,;8.72,-6.47,;8.55,-4.94,;9.96,-4.31,;10.99,-5.46,;12.53,-5.46,;13.3,-6.79,;12.53,-8.12,;10.99,-8.12,;10.22,-6.79,;13.3,-4.12,;12.53,-2.79,;13.3,-1.46,;14.84,-1.46,;15.61,-2.79,;14.84,-4.12,;7.22,-4.17,;5.73,-4.57,;5.33,-3.08,;6.82,-2.68,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-1.33,-2.31,;,-3.08,;1.33,-2.31,;2.67,-3.08,)|
Show InChI InChI=1S/C30H27N5O3/c36-30(37)21-7-5-20(6-8-21)28-27(33-29-26(11-12-31-35(28)29)34-13-15-38-16-14-34)23-17-22(18-23)25-10-9-19-3-1-2-4-24(19)32-25/h1-12,22-23H,13-18H2,(H,36,37)/t22-,23-
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n/an/a 0.600n/an/an/an/an/an/a



Janssen Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assay

Bioorg Med Chem Lett 26: 4216-22 (2016)


Article DOI: 10.1016/j.bmcl.2016.07.054
BindingDB Entry DOI: 10.7270/Q2X63RGK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198873
PNG
(US9221797, 45)
Show SMILES CC1CCCC(=C1C)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(C)(C)N1CCCC1 |c:5|
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n/an/a 0.600n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM119032
PNG
(US8674100, 45)
Show SMILES CC(C)(N1CCCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H33N5O/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31-13-5-6-14-31)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,5-6,10-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50393560
PNG
(CHEMBL2158300 | US8697716, 48)
Show SMILES CC(C)(N)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:32|
Show InChI InChI=1S/C27H34N6O2/c1-27(2,29)15-24(34)33-12-10-18(11-13-33)20-8-9-23(22(14-20)19-6-4-3-5-7-19)32-26(35)25-30-17-21(16-28)31-25/h6,8-9,14,17-18H,3-5,7,10-13,15,29H2,1-2H3,(H,30,31)(H,32,35)
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n/an/a 0.620n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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n/an/a 0.640n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50393549
PNG
(CHEMBL2158289)
Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:33|
Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)
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n/an/a 0.640n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198904
PNG
(US9221797, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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n/an/a 0.640n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238225
PNG
(US9403804, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)C(O)=O |r,wU:24.27,28.34,c:5,(-1.59,6.83,;-1.59,5.29,;-.82,6.62,;-.26,4.52,;-.26,2.98,;-1.59,2.21,;-2.93,2.98,;-2.93,4.52,;-1.59,.67,;-2.93,-.1,;-2.93,-1.64,;-1.59,-2.41,;-.26,-1.64,;-.26,-.1,;1.08,.67,;2.41,-.1,;2.41,-1.64,;3.74,.67,;5.21,.19,;6.11,1.44,;5.27,2.75,;3.74,2.21,;5.77,4.21,;6.27,5.67,;-4.26,-2.41,;-5.03,-1.08,;-5.59,-3.18,;-5.59,-4.72,;-4.26,-5.55,;-2.93,-4.72,;-2.93,-3.18,;-4.26,-7.09,;-5.59,-7.86,;-2.93,-7.86,)|
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n/an/a 0.650n/an/an/an/a7.525



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9403804 (2016)


BindingDB Entry DOI: 10.7270/Q23T9G3C
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238120
PNG
(US9394289, 16)
Show SMILES COC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C26H30N4O4/c1-25(2)8-6-17(7-9-25)20-14-18(26(24(32)33-3)10-12-34-13-11-26)4-5-21(20)30-23(31)22-28-16-19(15-27)29-22/h4-6,14,16H,7-13H2,1-3H3,(H,28,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM238111
PNG
(US9394289, 7)
Show SMILES CN(C)C1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(31(3)4)11-13-33-14-12-26)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...

US Patent US9394289 (2016)


BindingDB Entry DOI: 10.7270/Q28K780X
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50443167
PNG
(CHEMBL3085977 | US8674100, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198891
PNG
(US9221797, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(C(=O)NOC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C27H34N6O4/c1-17(34)29-12-13-31-27(4,5)19-6-7-21(22(14-19)18-8-10-26(2,3)11-9-18)24(35)33-37-25(36)23-30-16-20(15-28)32-23/h6-8,14,16,31H,9-13H2,1-5H3,(H,29,34)(H,30,32)(H,33,35)
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n/an/a 0.680n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241638
PNG
(US9409915, 21 | US9718820, Compound 21)
Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H25F3N6O2/c1-24(2,3)21-15(13-29)20(34(4)33-21)22-30-18-12-17(14-8-6-7-9-16(14)25(26,27)28)31-23(19(18)32-22)36-11-10-35-5/h6-9,12H,10-11H2,1-5H3,(H,30,32)
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n/an/a 0.690n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...

US Patent US9718820 (2017)


BindingDB Entry DOI: 10.7270/Q2RV0QQ5
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31|
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 0.690n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31|
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM119044
PNG
(CHEMBL3085833 | US8674100, 62 | US8674100, 63)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...

US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198878
PNG
(BDBM198879 | US9221797, 62)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM241638
PNG
(US9409915, 21 | US9718820, Compound 21)
Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H25F3N6O2/c1-24(2,3)21-15(13-29)20(34(4)33-21)22-30-18-12-17(14-8-6-7-9-16(14)25(26,27)28)31-23(19(18)32-22)36-11-10-35-5/h6-9,12H,10-11H2,1-5H3,(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...

US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50393562
PNG
(CHEMBL2158302)
Show SMILES OCCNC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31|
Show InChI InChI=1S/C25H30N6O3/c26-15-20-16-28-23(29-20)24(33)30-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-11-31(12-9-17)25(34)27-10-13-32/h4,6-7,14,16-17,32H,1-3,5,8-13H2,(H,27,34)(H,28,29)(H,30,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization

J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
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