Reaction Details |
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Target | Macrophage colony-stimulating factor 1 receptor |
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Ligand | BDBM50393549 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_857183 (CHEMBL2163157) |
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IC50 | 0.64±n/a nM |
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Citation | Illig, CR; Manthey, CL; Wall, MJ; Meegalla, SK; Chen, J; Wilson, KJ; Ballentine, SK; Desjarlais, RL; Schubert, C; Crysler, CS; Chen, Y; Molloy, CJ; Chaikin, MA; Donatelli, RR; Yurkow, E; Zhou, Z; Player, MR; Tomczuk, BE Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141). J Med Chem54:7860-83 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage colony-stimulating factor 1 receptor |
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Name: | Macrophage colony-stimulating factor 1 receptor |
Synonyms: | CSF1R_MOUSE | Csf1r | Csfmr | Fms | Macrophage colony-stimulating factor 1 receptor | Macrophage colony-stimulating factor 1 receptor (c-Fms) | Proto-oncogene c-Fms |
Type: | Protein |
Mol. Mass.: | 109173.45 |
Organism: | Mus musculus (Mouse) |
Description: | P09581 |
Residue: | 977 |
Sequence: | MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTL
DPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEG
QEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTM
VNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRG
DTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRY
TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVS
GYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMT
YFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQ
KPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDT
YVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCE
PGDIAQPLLQPNNYQFC
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BDBM50393549 |
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n/a |
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Name | BDBM50393549 |
Synonyms: | CHEMBL2158289 |
Type | Small organic molecule |
Emp. Form. | C27H34N6O3 |
Mol. Mass. | 490.5973 |
SMILES | CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:33| |
Structure |
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