Compile Data Set for Download or QSAR

Found 616 hits with Last Name = 'chaikin' and Initial = 'ma'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166693 (3-Pyridin-3-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]na...) Show SMILES OC(=O)CC(c1cccnc1)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C26H26N4O3/c31-25(32)16-24(20-4-1-11-27-17-20)30-13-9-19-15-22(7-8-23(19)30)33-14-10-21-6-5-18-3-2-12-28-26(18)29-21/h1,4-9,11,13,15,17,24H,2-3,10,12,14,16H2,(H,28,29)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166695 (3-(5-Methoxy-pyridin-3-yl)-3-{5-[2-(5,6,7,8-tetrah...) Show SMILES COc1cncc(c1)C(CC(O)=O)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H28N4O4/c1-34-23-14-20(16-28-17-23)25(15-26(32)33)31-11-8-19-13-22(6-7-24(19)31)35-12-9-21-5-4-18-3-2-10-29-27(18)30-21/h4-8,11,13-14,16-17,25H,2-3,9-10,12,15H2,1H3,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166677 (3-(5-Cyano-pyridin-3-yl)-3-{5-[2-(5,6,7,8-tetrahyd...) Show SMILES OC(=O)CC(c1cncc(c1)C#N)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H25N5O3/c28-15-18-12-21(17-29-16-18)25(14-26(33)34)32-10-7-20-13-23(5-6-24(20)32)35-11-8-22-4-3-19-2-1-9-30-27(19)31-22/h3-7,10,12-13,16-17,25H,1-2,8-9,11,14H2,(H,30,31)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321368 (4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...) Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28| Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166688 (3-(6-Methanesulfonyl-pyridin-3-yl)-3-{5-[2-(5,6,7,...) Show SMILES CS(=O)(=O)c1ccc(cn1)C(CC(O)=O)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H28N4O5S/c1-37(34,35)25-9-5-20(17-29-25)24(16-26(32)33)31-13-10-19-15-22(7-8-23(19)31)36-14-11-21-6-4-18-3-2-12-28-27(18)30-21/h4-10,13,15,17,24H,2-3,11-12,14,16H2,1H3,(H,28,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377072 (CHEMBL438533) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1 Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377072 (CHEMBL438533) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1 Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27912 (8-(4-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...) Show SMILES CCc1ccc(cc1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12 Show InChI InChI=1S/C29H32N6O3/c1-4-19-5-11-23(12-6-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-9-7-20(8-10-22)21-13-15-34(2)16-14-21/h5-12,17-18,21H,4,13-16H2,1-3H3,(H,33,37)(H,30,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166678 (3-Benzo[1,3]dioxol-5-yl-3-{5-[2-(5,6,7,8-tetrahydr...) Show SMILES OC(=O)CC(c1ccc2OCOc2c1)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C28H27N3O5/c32-27(33)16-24(19-4-8-25-26(15-19)36-17-35-25)31-12-9-20-14-22(6-7-23(20)31)34-13-10-21-5-3-18-2-1-11-29-28(18)30-21/h3-9,12,14-15,24H,1-2,10-11,13,16-17H2,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166683 (3-Quinolin-3-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]n...) Show SMILES OC(=O)CC(c1cnc2ccccc2c1)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C30H28N4O3/c35-29(36)18-28(23-16-21-4-1-2-6-26(21)32-19-23)34-14-11-22-17-25(9-10-27(22)34)37-15-12-24-8-7-20-5-3-13-31-30(20)33-24/h1-2,4,6-11,14,16-17,19,28H,3,5,12-13,15,18H2,(H,31,33)(H,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377071 (CHEMBL402337) Show SMILES CC1CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CCNCC1 |c:4| Show InChI InChI=1S/C23H27N5O/c1-15-2-4-17(5-3-15)20-12-18(16-8-10-25-11-9-16)6-7-21(20)28-23(29)22-26-14-19(13-24)27-22/h4,6-7,12,14-16,25H,2-3,5,8-11H2,1H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27909 (8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...) Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27913 (8-(3-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...) Show SMILES CCc1cccc(c1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12 Show InChI InChI=1S/C29H32N6O3/c1-4-19-6-5-7-23(16-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-10-8-20(9-11-22)21-12-14-34(2)15-13-21/h5-11,16-18,21H,4,12-15H2,1-3H3,(H,33,37)(H,30,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27915 (8-(4,4-dimethylcyclohexyl)-N-methoxy-2-{[4-(1-meth...) Show SMILES CONC(=O)c1cn(C2CCC(C)(C)CC2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O Show InChI InChI=1S/C29H38N6O3/c1-29(2)13-9-22(10-14-29)35-18-24(27(37)33-38-4)25(36)23-17-30-28(32-26(23)35)31-21-7-5-19(6-8-21)20-11-15-34(3)16-12-20/h5-8,17-18,20,22H,9-16H2,1-4H3,(H,33,37)(H,30,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321373 (4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...) Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30| Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166669 (3-(5-Methanesulfonyl-pyridin-3-yl)-3-{5-[2-(5,6,7,...) Show SMILES CS(=O)(=O)c1cncc(c1)C(CC(O)=O)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H28N4O5S/c1-37(34,35)23-14-20(16-28-17-23)25(15-26(32)33)31-11-8-19-13-22(6-7-24(19)31)36-12-9-21-5-4-18-3-2-10-29-27(18)30-21/h4-8,11,13-14,16-17,25H,2-3,9-10,12,15H2,1H3,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166675 (3-(3-Chloro-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[1...) Show SMILES OC(=O)CC(c1cccc(Cl)c1)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H26ClN3O3/c28-21-5-1-3-19(15-21)25(17-26(32)33)31-13-10-20-16-23(8-9-24(20)31)34-14-11-22-7-6-18-4-2-12-29-27(18)30-22/h1,3,5-10,13,15-16,25H,2,4,11-12,14,17H2,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27896 (8-(2,3-dihydro-1H-inden-5-yl)-N-ethoxy-2-({4-[2-(4...) Show SMILES CCONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O Show InChI InChI=1S/C32H37N7O3/c1-3-42-36-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-33-32(35-30)34-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,36,41)(H,33,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27906 (8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...) Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O Show InChI InChI=1S/C29H30N6O3/c1-38-34-28(37)25-17-35(23-10-7-18-3-2-4-21(18)15-23)27-24(26(25)36)16-31-29(33-27)32-22-8-5-19(6-9-22)20-11-13-30-14-12-20/h5-10,15-17,20,30H,2-4,11-14H2,1H3,(H,34,37)(H,31,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321365 (4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...) Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28| Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321367 (4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...) Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28| Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27897 (8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...) Show SMILES CC(C)ONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O Show InChI InChI=1S/C33H39N7O3/c1-22(2)43-37-32(42)29-21-40(27-12-9-24-5-4-6-25(24)19-27)31-28(30(29)41)20-34-33(36-31)35-26-10-7-23(8-11-26)13-14-39-17-15-38(3)16-18-39/h7-12,19-22H,4-6,13-18H2,1-3H3,(H,37,42)(H,34,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443154 (CHEMBL3085973 | US8674100, 147) Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27| Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM119049 (CHEMBL3086320 | US8674100, 20 | US8674100, 69) Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26| Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233716 (5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1 Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393560 (CHEMBL2158300 | US8697716, 48) Show SMILES CC(C)(N)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:32| Show InChI InChI=1S/C27H34N6O2/c1-27(2,29)15-24(34)33-12-10-18(11-13-33)20-8-9-23(22(14-20)19-6-4-3-5-7-19)32-26(35)25-30-17-21(16-28)31-25/h6,8-9,14,17-18H,3-5,7,10-13,15,29H2,1-2H3,(H,30,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM50393549 (CHEMBL2158289) Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:33| Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50355499 (CHEMBL1908395 | CHEMBL1908842) Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50355499 (CHEMBL1908395 | CHEMBL1908842) Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27895 (8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...) Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233720 (CHEMBL254909 | N-(4-(4-acetylpiperazin-1-yl)-2-(4-...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H30N6O2/c1-17-5-7-30(8-6-17)23-14-20(29-11-9-28(10-12-29)18(2)31)3-4-21(23)27-24(32)22-13-19(15-25)16-26-22/h3-4,13-14,16-17,26H,5-12H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233701 (5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lam...) Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)N1CCS(=O)(=O)CC1)c1ccc(o1)C#N Show InChI InChI=1S/C21H24N4O4S/c22-15-17-5-7-20(29-17)21(26)23-18-6-4-16(24-10-12-30(27,28)13-11-24)14-19(18)25-8-2-1-3-9-25/h4-7,14H,1-3,8-13H2,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166680 (3-(4-Methoxy-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[...) Show SMILES COc1ccc(cc1)C(CC(O)=O)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C28H29N3O4/c1-34-23-8-5-19(6-9-23)26(18-27(32)33)31-15-12-21-17-24(10-11-25(21)31)35-16-13-22-7-4-20-3-2-14-29-28(20)30-22/h4-12,15,17,26H,2-3,13-14,16,18H2,1H3,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27910 (2-{[4-(3,3-difluoro-1-methylpiperidin-4-yl)phenyl]...) Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3(F)F)ncc2c1=O Show InChI InChI=1S/C30H30F2N6O3/c1-37-13-12-25(30(31,32)17-37)19-6-9-21(10-7-19)34-29-33-15-23-26(39)24(28(40)36-41-2)16-38(27(23)35-29)22-11-8-18-4-3-5-20(18)14-22/h6-11,14-16,25H,3-5,12-13,17H2,1-2H3,(H,36,40)(H,33,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27894 (8-(2,3-dihydro-1H-inden-5-yl)-N-(2-hydroxyethyl)-2...) Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(=O)NCCO)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C32H37N7O3/c1-37-14-16-38(17-15-37)13-11-22-5-8-25(9-6-22)35-32-34-20-27-29(41)28(31(42)33-12-18-40)21-39(30(27)36-32)26-10-7-23-3-2-4-24(23)19-26/h5-10,19-21,40H,2-4,11-18H2,1H3,(H,33,42)(H,34,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166668 (3-(4-Fluoro-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[1...) Show SMILES OC(=O)CC(c1ccc(F)cc1)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C27H26FN3O3/c28-21-6-3-18(4-7-21)25(17-26(32)33)31-14-11-20-16-23(9-10-24(20)31)34-15-12-22-8-5-19-2-1-13-29-27(19)30-22/h3-11,14,16,25H,1-2,12-13,15,17H2,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443167 (CHEMBL3085977 | US8674100, 76) Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28| Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM119044 (CHEMBL3085833 | US8674100, 62 | US8674100, 63) Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31| Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393562 (CHEMBL2158302) Show SMILES OCCNC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C25H30N6O3/c26-15-20-16-28-23(29-20)24(33)30-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-11-31(12-9-17)25(34)27-10-13-32/h4,6-7,14,16-17,32H,1-3,5,8-13H2,(H,27,34)(H,28,29)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377060 (CHEMBL255443) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1=CCNCC1 |t:26| Show InChI InChI=1S/C23H26N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-6,14,16,25H,7-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321364 (4-cyano-N-(2-(4,4-dimethylcyclohex-1-enyl)-4-(2,6-...) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(=O)NC(=O)C1 |c:5| Show InChI InChI=1S/C24H25N5O3/c1-24(2)7-5-14(6-8-24)18-9-15(16-10-20(30)29-21(31)11-16)3-4-19(18)28-23(32)22-26-13-17(12-25)27-22/h3-5,9,13,16H,6-8,10-11H2,1-2H3,(H,26,27)(H,28,32)(H,29,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50166682 (3-(3-Methoxy-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[...) Show SMILES COc1cccc(c1)C(CC(O)=O)n1ccc2cc(OCCc3ccc4CCCNc4n3)ccc12 Show InChI InChI=1S/C28H29N3O4/c1-34-23-6-2-4-20(16-23)26(18-27(32)33)31-14-11-21-17-24(9-10-25(21)31)35-15-12-22-8-7-19-5-3-13-29-28(19)30-22/h2,4,6-11,14,16-17,26H,3,5,12-13,15,18H2,1H3,(H,29,30)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C. Curated by ChEMBL					Assay Description Inhibitory concentration against alphaV-beta3 integrin				Bioorg Med Chem Lett 15: 2679-84 (2005) Article DOI: 10.1016/j.bmcl.2005.01.028 BindingDB Entry DOI: 10.7270/Q2N29Z40
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233715 (5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1 Show InChI InChI=1S/C22H27N5O2/c1-25-11-13-26(14-12-25)17-5-7-19(20(15-17)27-9-3-2-4-10-27)24-22(28)21-8-6-18(16-23)29-21/h5-8,15H,2-4,9-14H2,1H3,(H,24,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27890 (8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...) Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C30H33N7O2/c1-35-13-15-36(16-14-35)12-11-20-5-8-23(9-6-20)33-30-32-18-25-27(38)26(28(31)39)19-37(29(25)34-30)24-10-7-21-3-2-4-22(21)17-24/h5-10,17-19H,2-4,11-16H2,1H3,(H2,31,39)(H,32,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27904 (8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...) Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)C(=O)C4)cc3)ncc2c1=O Show InChI InChI=1S/C31H33N7O4/c1-36-14-15-37(19-27(36)39)13-12-20-6-9-23(10-7-20)33-31-32-17-25-28(40)26(30(41)35-42-2)18-38(29(25)34-31)24-11-8-21-4-3-5-22(21)16-24/h6-11,16-18H,3-5,12-15,19H2,1-2H3,(H,35,41)(H,32,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377059 (CHEMBL257620) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H30N4O3/c1-17-7-11-29(12-8-17)23-15-20(19-9-13-28(14-10-19)18(2)30)3-5-22(23)27-25(31)24-6-4-21(16-26)32-24/h3-6,15,17,19H,7-14H2,1-2H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair

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