| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Ligand | BDBM25730 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen |
|---|
| IC50 | 805±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Name: | NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Synonyms: | C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 118173.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96P20 |
|---|
| Residue: | 1036 |
|---|
| Sequence: | MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
|
|
|
|---|
| BDBM25730 |
|---|
| n/a |
|---|
| Name | BDBM25730 |
|---|
| Synonyms: | 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US10383835, Compound 295 | US8815951, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | Urea-based compound, 11 | cid_7547 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H9Cl3N2O |
|---|
| Mol. Mass. | 315.582 |
|---|
| SMILES | Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
