Reaction Details |
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Target | Proteasome subunit beta type-5 |
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Ligand | BDBM50242224 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1670822 (CHEMBL4020851) |
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IC50 | 510±n/a nM |
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Citation | Zhu, M; Harshbarger, WD; Robles, O; Krysiak, J; Hull, KG; Cho, SW; Richardson, RD; Yang, Y; Garcia, A; Spiegelman, L; Ramirez, B; Wilson, CT; Yau, JA; Moore, JT; Walker, CB; Sacchettini, JC; Liu, WR; Sieber, SA; Smith, JW; Romo, D A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorg Med Chem25:2901-2916 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteasome subunit beta type-5 |
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Name: | Proteasome subunit beta type-5 |
Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
Type: | Protein |
Mol. Mass.: | 28480.96 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 263 |
Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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BDBM50242224 |
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n/a |
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Name | BDBM50242224 |
Synonyms: | CHEMBL4070939 |
Type | Small organic molecule |
Emp. Form. | C27H37N3O7 |
Mol. Mass. | 515.5986 |
SMILES | CCCCCC[C@H]1[C@@H](OC1=O)C(=O)NCCCC[C@@H]1NC(=O)N([C@@H](C)C(=O)OCc2ccccc2)C1=O |r| |
Structure |
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