Reaction Details |
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Target | Neuronal acetylcholine receptor subunit alpha-3/beta-4 |
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Ligand | BDBM50246824 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1676966 (CHEMBL4027109) |
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Ki | 50107±n/a nM |
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Citation | Wu, J; Cippitelli, A; Zhang, Y; Debevec, G; Schoch, J; Ozawa, A; Yu, Y; Liu, H; Chen, W; Houghten, RA; Welmaker, GS; Giulianotti, MA; Toll, L Highly Selective and Potent?4?2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. J Med Chem60:10092-10104 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit alpha-3/beta-4 |
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Name: | Neuronal acetylcholine receptor subunit alpha-3/beta-4 |
Synonyms: | Neuronal acetylcholine receptor Alpha-3/Beta-4 | Neuronal acetylcholine receptor protein alpha-3/beta-4 subunit | Neuronal acetylcholine receptor; alpha3/beta4 | nAChR subtypes alpha3 beta4 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Neuronal acetylcholine receptor subunit alpha-3 |
Synonyms: | ACHA3_RAT | Acra3 | Chrna3 |
Type: | Enzyme |
Mol. Mass.: | 56995.52 |
Organism: | Rattus norvegicus (Rat) |
Description: | P04757 |
Residue: | 499 |
Sequence: | MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEV
SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNN
ADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK
IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTI
NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE
YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDT
PKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSE
SVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILV
CILGTAGLFLQPLMARDDT
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Component 2 |
Name: | Neuronal acetylcholine receptor subunit beta-4 |
Synonyms: | ACHB4_RAT | Acrb4 | Chrnb4 | N-alpha 2 | Neuronal acetylcholine receptor non-alpha-2
chain | Neuronal acetylcholine receptor protein beta-4 subunit |
Type: | Enzyme |
Mol. Mass.: | 55863.89 |
Organism: | Rattus norvegicus (Rat) |
Description: | P12392 |
Residue: | 495 |
Sequence: | MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELS
LSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNA
DGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEI
DMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLII
PCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLF
TMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPH
PSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSS
GRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGL
FLPPLFQIHAPSKDS
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BDBM50246824 |
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n/a |
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Name | BDBM50246824 |
Synonyms: | CHEMBL4081815 |
Type | Small organic molecule |
Emp. Form. | C9H12N4 |
Mol. Mass. | 176.2184 |
SMILES | N=C1NCCN1Cc1ccncc1 |
Structure |
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