| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50249583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1680080 |
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| IC50 | >30000±n/a nM |
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| Citation |  Piizzi, G; Parker, DT; Peng, Y; Dobler, M; Patnaik, A; Wattanasin, S; Liu, E; Lenoir, F; Nunez, J; Kerrigan, J; McKenney, D; Osborne, C; Yu, D; Lanieri, L; Bojkovic, J; Dzink-Fox, J; Lilly, MD; Sprague, ER; Lu, Y; Wang, H; Ranjitkar, S; Xie, L; Wang, B; Glick, M; Hamann, LG; Tommasi, R; Yang, X; Dean, CR Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. J Med Chem60:5002-5014 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50249583 |
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| n/a |
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| Name | BDBM50249583 |
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| Synonyms: | CHEMBL4097399 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N3O4 |
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| Mol. Mass. | 319.3556 |
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| SMILES | CC#CCOc1ccc(cc1)C(=O)N[C@H](C(=O)NO)C(C)(C)N |r| |
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| Structure | 
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