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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 4-hydroxyphenylpyruvate dioxygenase | ||
| Ligand | BDBM50264309 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1698554 (CHEMBL4049536) | ||
| Ki | 7.0±n/a nM | ||
| Citation |  Santucci, A; Bernardini, G; Braconi, D; Petricci, E; Manetti, F 4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases. J Med Chem60:4101-4125 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 4-hydroxyphenylpyruvate dioxygenase | |||
| Name: | 4-hydroxyphenylpyruvate dioxygenase | ||
| Synonyms: | 1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_ARATH | PDS1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48808.34 | ||
| Organism: | Arabidopsis thaliana | ||
| Description: | ChEMBL_105530 | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50264309 | |||
| n/a | |||
| Name | BDBM50264309 | ||
| Synonyms: | CHEMBL4060588 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H16N2O3 | ||
| Mol. Mass. | 320.3419 | ||
| SMILES | CC1CC(=O)C(C(=O)c2cc3cccc(C)c3nc2C#N)C(=O)C1 |(52.99,-30.01,;54.32,-29.24,;54.32,-27.7,;55.65,-26.92,;55.65,-25.38,;56.98,-27.7,;58.32,-26.93,;58.32,-25.39,;59.65,-27.71,;59.64,-29.25,;60.97,-30.02,;60.97,-31.55,;62.3,-32.32,;63.63,-31.55,;63.63,-30.02,;64.96,-29.24,;62.3,-29.25,;62.31,-27.71,;60.98,-26.94,;60.97,-25.41,;60.97,-23.87,;56.98,-29.24,;58.31,-30.01,;55.65,-30,)| | ||
| Structure | 
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