Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50269772 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1707177 | ||
| IC50 | 16±n/a nM | ||
| Citation |  Anan, K; Masui, M; Hara, S; Ohara, M; Kume, M; Yamamoto, S; Shinohara, S; Tsuji, H; Shimada, S; Yagi, S; Hasebe, N; Kai, H Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorg Med Chem Lett27:4194-4198 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
| ||
| BDBM50269772 | |||
| n/a | |||
| Name | BDBM50269772 | ||
| Synonyms: | CHEMBL4094573 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24N2O4 | ||
| Mol. Mass. | 380.437 | ||
| SMILES | O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,18.20,(12.23,-7.56,;13,-8.9,;11.46,-8.9,;10.69,-10.23,;11.46,-11.57,;9.15,-10.23,;8.38,-11.57,;9.16,-12.89,;8.4,-14.22,;6.85,-14.23,;5.82,-15.38,;4.41,-14.75,;3.08,-15.53,;4.56,-13.22,;6.07,-12.89,;6.85,-11.56,;14.33,-8.12,;15.66,-8.9,;15.66,-10.44,;17,-11.21,;18.33,-10.44,;19.66,-11.22,;20.99,-10.45,;21,-8.91,;19.65,-8.14,;18.33,-8.91,;14.33,-11.2,;13,-10.44,)| | ||
| Structure | 
| ||