Reaction Details | |||
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Target | Glutamate receptor ionotropic, NMDA 2B | ||
Ligand | BDBM50269752 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1707178 | ||
IC50 | 1.000000±n/a nM | ||
Citation | Anan, K; Masui, M; Hara, S; Ohara, M; Kume, M; Yamamoto, S; Shinohara, S; Tsuji, H; Shimada, S; Yagi, S; Hasebe, N; Kai, H Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach. Bioorg Med Chem Lett27:4194-4198 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glutamate receptor ionotropic, NMDA 2B | |||
Name: | Glutamate receptor ionotropic, NMDA 2B | ||
Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate receptor ionotropic, NMDA 2B | Grin2b | Ionotropic glutamate receptor NMDA1/2B | N-methyl D-aspartate receptor subtype 2B | NMDAR2B | NMDE2_MOUSE | NR2B | ||
Type: | PROTEIN | ||
Mol. Mass.: | 165965.49 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_117725 | ||
Residue: | 1482 | ||
Sequence: |
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BDBM50269752 | |||
n/a | |||
Name | BDBM50269752 | ||
Synonyms: | CHEMBL4078903 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23ClN2O3 | ||
Mol. Mass. | 398.883 | ||
SMILES | O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;17.79,-8.22,;19.12,-9,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;17.79,-11.3,;16.46,-10.54,)| | ||
Structure |