| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 12 |
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| Ligand | BDBM50271256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1709819 (CHEMBL4119868) |
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| IC50 | 1700±n/a nM |
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| Citation |  Patel, S; Meilandt, WJ; Erickson, RI; Chen, J; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, W; Liu, X; Liu, Y; Lyssikatos, JP; Ma, C; Yin, J; Lewcock, JW; Siu, M Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem60:8083-8102 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 12 |
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| Name: | Mitogen-activated protein kinase kinase kinase 12 |
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| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93216.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460553 |
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| Residue: | 859 |
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| Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
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| BDBM50271256 |
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| n/a |
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| Name | BDBM50271256 |
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| Synonyms: | CHEMBL3718750 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26ClN5O |
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| Mol. Mass. | 375.896 |
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| SMILES | CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(Cl)c1 |
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| Structure | 
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