| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50273526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713036 (CHEMBL4123085) |
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| IC50 | >10000±n/a nM |
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| Citation |  Martin, MW; Lee, JY; Lancia, DR; Ng, PY; Han, B; Thomason, JR; Lynes, MS; Marshall, CG; Conti, C; Collis, A; Morales, MA; Doshi, K; Rudnitskaya, A; Yao, L; Zheng, X Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11. Bioorg Med Chem Lett28:2143-2147 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50273526 |
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| n/a |
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| Name | BDBM50273526 |
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| Synonyms: | CHEMBL4126661 | US11535607, Example 22-8 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15F3N4O2 |
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| Mol. Mass. | 352.3111 |
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| SMILES | CC1(C)N(Cc2c1cccc2C(=O)NO)c1cnc(cn1)C(F)(F)F |
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| Structure | 
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