| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell lymphoma 6 protein |
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| Ligand | BDBM50366279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1735217 (CHEMBL4150753) |
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| IC50 | 34000±n/a nM |
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| Citation |  Cheng, H; Linhares, BM; Yu, W; Cardenas, MG; Ai, Y; Jiang, W; Winkler, A; Cohen, S; Melnick, A; MacKerell, A; Cierpicki, T; Xue, F Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J Med Chem61:7573-7588 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell lymphoma 6 protein |
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| Name: | B-cell lymphoma 6 protein |
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| Synonyms: | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78866.89 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117695 |
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| Residue: | 706 |
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| Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
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| BDBM50366279 |
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| n/a |
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| Name | BDBM50366279 |
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| Synonyms: | CHEMBL4165932 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N7OS |
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| Mol. Mass. | 571.779 |
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| SMILES | CN1CCN(Cc2cn(CC(=O)N3CCCCC3)c3cc(NC(=S)NCCc4c[nH]c5ccccc45)ccc23)CC1 |
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| Structure | 
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