| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-14 |
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| Ligand | BDBM50450401 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1742472 (CHEMBL4158222) |
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| IC50 | >5000±n/a nM |
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| Citation |  Fuerst, R; Yong Choi, J; Knapinska, AM; Smith, L; Cameron, MD; Ruiz, C; Fields, GB; Roush, WR Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study. Bioorg Med Chem26:4984-4995 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-14 |
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| Name: | Matrix metalloproteinase-14 |
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| Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
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| Type: | Protein |
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| Mol. Mass.: | 65900.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50281 |
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| Residue: | 582 |
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| Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
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| BDBM50450401 |
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| n/a |
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| Name | BDBM50450401 |
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| Synonyms: | CHEMBL4161914 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N4O4S |
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| Mol. Mass. | 506.617 |
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| SMILES | CC(C)[C@H](NC(=O)c1ccc(o1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1)C(=O)NC1CC1 |r| |
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| Structure | 
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