| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosinase precursor |
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| Ligand | BDBM50104891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1745945 (CHEMBL4180455) |
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| IC50 | 102800±n/a nM |
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| Citation |  Veselinovi?, JB; Veselinovi?, AM; Ilic-Tomic, T; Davis, R; O'Connor, K; Pavic, A; Nikodinovic-Runic, J Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies. Bioorg Med Chem25:6286-6296 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosinase precursor |
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| Name: | Tyrosinase precursor |
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| Synonyms: | tyr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60583.76 |
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| Organism: | Danio rerio |
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| Description: | ChEMBL_118130 |
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| Residue: | 534 |
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| Sequence: | MSLHLLLFFLQLFSSSLQQFPRVCTSPEVLQSKRCCPVWPGDGSVCGVQSGRGFCQDVLV
SDLPNGPQYPHSGVDDRERWPLVFYNQTCQCAGNYMGFDCGECKFGFFGANCAERRESVR
RNIFQLSTTERQRFISYLNLAKTTISPDYMIVTGTYAQMNNGSTPMFANISVYDLFVWMH
YYVSRDALLGGPGNVWADIDFAHESAAFLPWHRVYLLFWEHEIRKLTGDFNFTIPYWDWR
DAQDCQVCTDELMGARSSLNRSLISPSSVFSSWKVICSQPESYNLREALCDGSPEGPLLR
NPGDHDRIRVPRLPTSADVESVLRLTDYETGQMDRRANLSFRNALEGFANPETGLAVTGR
SLMHNSLHVFMNGSMSSVQGSANDPIFIIHHAFIDSIFEQWLRRHQPPRTHYPTANAPIG
HNDGYFMVPFIPLYRNGDYFLSTKALGYEYAYLQDPGQRFVQEFLTPYLEQAQQIWQWLV
AAGILGAAVAGIIASVFAVACRRQTRRRKLSYGERQPLLNSSEEEGSASYQTTL
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| BDBM50104891 |
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| n/a |
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| Name | BDBM50104891 |
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| Synonyms: | 7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phenyl-2H-chromen-2-one | CHEMBL325841 | Coumarin derivative, 3c | cid_5357479 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10O3 |
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| Mol. Mass. | 238.2381 |
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| SMILES | Oc1ccc2c(cc(=O)oc2c1)-c1ccccc1 |
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| Structure | 
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