| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
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| Ligand | BDBM50454217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1752434 (CHEMBL4187194) |
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| IC50 | 175±n/a nM |
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| Citation |  Monastyrskyi, A; Nilchan, N; Quereda, V; Noguchi, Y; Ruiz, C; Grant, W; Cameron, M; Duckett, D; Roush, W Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer. Bioorg Med Chem26:590-602 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform delta |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta) |
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| Type: | Enzyme |
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| Mol. Mass.: | 47356.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48730 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM50454217 |
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| n/a |
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| Name | BDBM50454217 |
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| Synonyms: | CHEMBL4205151 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F2N9O |
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| Mol. Mass. | 463.4428 |
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| SMILES | Fc1cc2nc(CNc3nc(nc4n(cnc34)-c3cccnc3)N3CCOCC3)[nH]c2cc1F |
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| Structure | 
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