| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
|---|
| Ligand | BDBM50454217 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1752435 (CHEMBL4187195) |
|---|
| IC50 | 340±n/a nM |
|---|
| Citation |  Monastyrskyi, A; Nilchan, N; Quereda, V; Noguchi, Y; Ruiz, C; Grant, W; Cameron, M; Duckett, D; Roush, W Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer. Bioorg Med Chem26:590-602 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase I isoform epsilon |
|---|
| Name: | Casein kinase I isoform epsilon |
|---|
| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47340.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49674 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
|
|
|
|---|
| BDBM50454217 |
|---|
| n/a |
|---|
| Name | BDBM50454217 |
|---|
| Synonyms: | CHEMBL4205151 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F2N9O |
|---|
| Mol. Mass. | 463.4428 |
|---|
| SMILES | Fc1cc2nc(CNc3nc(nc4n(cnc34)-c3cccnc3)N3CCOCC3)[nH]c2cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
