| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 8 |
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| Ligand | BDBM50459996 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1768132 (CHEMBL4220244) |
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| IC50 | 17±n/a nM |
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| Citation |  Philip, S; Kumarasiri, M; Teo, T; Yu, M; Wang, S Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy? J Med Chem61:5073-5092 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 8 |
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| Name: | Cyclin-dependent kinase 8 |
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| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 53300.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49336 |
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| Residue: | 464 |
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| Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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| BDBM50459996 |
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| n/a |
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| Name | BDBM50459996 |
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| Synonyms: | CHEMBL4227266 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33F3N8O |
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| Mol. Mass. | 506.567 |
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| SMILES | CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3CCN(C3)c3ccnc(NC)n3)cc2C(F)(F)F)CC1 |r| |
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| Structure | 
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