| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4D |
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| Ligand | BDBM191600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771189 (CHEMBL4223301) |
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| IC50 | 110±n/a nM |
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| Citation |  Nie, Z; Shi, L; Lai, C; O'Connell, SM; Xu, J; Stansfield, RK; Hosfield, DJ; Veal, JM; Stafford, JA Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg Med Chem Lett28:1490-1494 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4D |
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| Name: | Lysine-specific demethylase 4D |
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| Synonyms: | JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58627.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_102441 |
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| Residue: | 523 |
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| Sequence: | METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED
LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL
YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA
FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW
IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST
QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA
AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT
CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
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| BDBM191600 |
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| n/a |
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| Name | BDBM191600 |
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| Synonyms: | 2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl)isonicotinic acid (N19) | US10173996, Example 89 | US9604961, Example 89 | US9714230, 89 | US9908865, Example 89 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14ClN3O3 |
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| Mol. Mass. | 343.764 |
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| SMILES | Cc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O |
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| Structure | 
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