| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 2 |
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| Ligand | BDBM50461631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771680 (CHEMBL4223792) |
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| Ki | 8420±n/a nM |
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| Citation |  Wodtke, R; Hauser, C; Ruiz-Gómez, G; Jäckel, E; Bauer, D; Lohse, M; Wong, A; Pufe, J; Ludwig, FA; Fischer, S; Hauser, S; Greif, D; Pisabarro, MT; Pietzsch, J; Pietsch, M; Löser, R N J Med Chem61:4528-4560 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase 2 |
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| Name: | Protein-glutamine gamma-glutamyltransferase 2 |
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| Synonyms: | Protein-glutamine gamma-glutamyltransferase | Protein-glutamine gamma-glutamyltransferase 2 (TG2) | TGM2 | TGM2_HUMAN | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2 |
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| Type: | Protein |
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| Mol. Mass.: | 77309.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21980 |
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| Residue: | 687 |
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| Sequence: | MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
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| BDBM50461631 |
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| n/a |
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| Name | BDBM50461631 |
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| Synonyms: | CHEMBL4225490 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N5O3 |
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| Mol. Mass. | 463.5719 |
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| SMILES | C=CC(=O)NCCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1CCN(CC1)c1ccccn1 |r| |
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| Structure | 
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