| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C beta type |
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| Ligand | BDBM50462709 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1776391 (CHEMBL4233383) |
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| IC50 | >1000±n/a nM |
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| Citation |  Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups. Bioorg Med Chem Lett28:2616-2621 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C beta type |
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| Name: | Protein kinase C beta type |
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| Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76873.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
|
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| Residue: | 671 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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| BDBM50462709 |
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| n/a |
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| Name | BDBM50462709 |
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| Synonyms: | CHEMBL4245507 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N5O2S |
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| Mol. Mass. | 437.558 |
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| SMILES | O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 |
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| Structure | 
|
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