| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase subunit beta-1 |
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| Ligand | BDBM50463100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1777636 (CHEMBL4234628) |
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| IC50 | 11000±n/a nM |
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| Citation |  Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem61:7273-7288 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase subunit beta-1 |
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| Name: | 5'-AMP-activated protein kinase subunit beta-1 |
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| Synonyms: | 5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1 |
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| Type: | n/a |
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| Mol. Mass.: | 30380.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y478 |
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| Residue: | 270 |
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| Sequence: | MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
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| BDBM50463100 |
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| n/a |
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| Name | BDBM50463100 |
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| Synonyms: | CHEMBL4249790 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24ClNO9 |
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| Mol. Mass. | 517.912 |
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| SMILES | O[C@@H]1[C@@H](O)[C@H](OC(=O)c2c[nH]c3cc(Cl)c(cc23)-c2ccc(cc2)C2(O)CCC2)O[C@@H]([C@H]1O)C(O)=O |r| |
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| Structure | 
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