| Reaction Details |
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 | Report a problem with these data |
| Target | DNA repair protein REV1 |
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| Ligand | BDBM50463118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1777721 (CHEMBL4234713) |
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| IC50 | 5900±n/a nM |
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| Citation |  Ozen, Z; Dash, RC; McCarthy, KR; Chow, SA; Rizzo, AA; Korzhnev, DM; Hadden, MK Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction. Bioorg Med Chem26:4301-4309 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA repair protein REV1 |
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| Name: | DNA repair protein REV1 |
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| Synonyms: | 2.7.7.- | AIBP80 | Alpha integrin-binding protein 80 | DNA repair protein REV1 | REV1 | REV1L | REV1_HUMAN | Rev1-like terminal deoxycytidyl transferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138277.17 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118218 |
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| Residue: | 1251 |
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| Sequence: | MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYT
DPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKA
GRLLSYIPYQLYTKQSSVQKGLSFNPVCRPEDPLPGPSNIAKQLNNRVNHIVKKIETENE
VKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIFNGHTPSSNGALKTQD
CLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSL
SPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHH
ISMWKCELTEFVNTLQRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIM
HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAA
DIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVP
YDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKD
QTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKL
ASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGI
RFTQPKEAEAFLLSLSEEIQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNI
ARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTNLNPSTCPSRPSV
QSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPT
SPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVCAV
QQAESHGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQESNSDAGINLIALPAFSQVDPEV
FAALPAELQRELKAAYDQRQRQGENSTHQQSASASVPKNPLLHLKAAVKEKKRNKKKKTI
GSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTSGVPG
LSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEE
KDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT
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| BDBM50463118 |
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| n/a |
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| Name | BDBM50463118 |
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| Synonyms: | CHEMBL4246571 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N4O3S |
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| Mol. Mass. | 390.5 |
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| SMILES | CCCCc1ccc(cc1)-n1nnc(C(=O)N(C)C2CCS(=O)(=O)C2)c1C |
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| Structure | 
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