Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50468978 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1801788 (CHEMBL4274080) |
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IC50 | 1602±n/a nM |
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Citation | Brindisi, M; Senger, J; Cavella, C; Grillo, A; Chemi, G; Gemma, S; Cucinella, DM; Lamponi, S; Sarno, F; Iside, C; Nebbioso, A; Novellino, E; Shaik, TB; Romier, C; Herp, D; Jung, M; Butini, S; Campiani, G; Altucci, L; Brogi, S Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies. Eur J Med Chem157:127-138 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50468978 |
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n/a |
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Name | BDBM50468978 |
Synonyms: | CHEMBL4291778 |
Type | Small organic molecule |
Emp. Form. | C25H31N3O4 |
Mol. Mass. | 437.5313 |
SMILES | CC(C)(C)OC(=O)N1CCC2(CN(Cc3ccc(cc3)C(=O)NO)c3ccccc23)CC1 |
Structure |
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