| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50468975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1801788 (CHEMBL4274080) |
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| IC50 | 253±n/a nM |
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| Citation |  Brindisi, M; Senger, J; Cavella, C; Grillo, A; Chemi, G; Gemma, S; Cucinella, DM; Lamponi, S; Sarno, F; Iside, C; Nebbioso, A; Novellino, E; Shaik, TB; Romier, C; Herp, D; Jung, M; Butini, S; Campiani, G; Altucci, L; Brogi, S Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies. Eur J Med Chem157:127-138 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50468975 |
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| n/a |
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| Name | BDBM50468975 |
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| Synonyms: | CHEMBL4283913 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O2 |
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| Mol. Mass. | 336.4275 |
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| SMILES | ONC(=O)c1ccc(CN2CC3(CCCCC3)c3ccccc23)cc1 |
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| Structure | 
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