Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase TBK1 |
---|
Ligand | BDBM357857 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1803718 (CHEMBL4276010) |
---|
IC50 | 851±n/a nM |
---|
Citation | Beyett, TS; Gan, X; Reilly, SM; Gomez, AV; Chang, L; Tesmer, JJG; Saltiel, AR; Showalter, HD Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK? for the treatment of obesity. Bioorg Med Chem26:5443-5461 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase TBK1 |
---|
Name: | Serine/threonine-protein kinase TBK1 |
Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
Type: | protein |
Mol. Mass.: | 83645.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHD2 |
Residue: | 729 |
Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
|
|
|
BDBM357857 |
---|
n/a |
---|
Name | BDBM357857 |
Synonyms: | Aphthasol | US10214536, Amlexanox |
Type | Small organic molecule |
Emp. Form. | C16H14N2O4 |
Mol. Mass. | 298.2934 |
SMILES | CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O |
Structure |
|