| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM50477954 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461924 (CHEMBL944771) |
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| IC50 | 20±n/a nM |
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| Citation |  Zhao, Z; Wolkenberg, SE; Sanderson, PE; Lu, M; Munshi, V; Moyer, G; Feng, M; Carella, AV; Ecto, LT; Gabryelski, LJ; Lai, MT; Prasad, SG; Yan, Y; McGaughey, GB; Miller, MD; Lindsley, CW; Hartman, GD; Vacca, JP; Williams, TM Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Bioorg Med Chem Lett18:554-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM50477954 |
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| n/a |
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| Name | BDBM50477954 |
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| Synonyms: | CHEMBL252405 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18BrClFN3O3S |
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| Mol. Mass. | 514.796 |
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| SMILES | Fc1cccc(Cl)c1CNC(=O)c1[nH]c2ccc(Br)cc2c1S(=O)(=O)N1CCCC1 |
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| Structure | 
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