Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50481373 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_605263 (CHEMBL1069343) |
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IC50 | >10000±n/a nM |
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Citation | Stanton, MG; Hubbs, J; Sloman, D; Hamblett, C; Andrade, P; Angagaw, M; Bi, G; Black, RM; Crispino, J; Cruz, JC; Fan, E; Farris, G; Hughes, BL; Kenific, CM; Middleton, RE; Nikov, G; Sajonz, P; Shah, S; Shomer, N; Szewczak, AA; Tanga, F; Tudge, MT; Shearman, M; Munoz, B Fluorinated piperidine acetic acids as gamma-secretase modulators. Bioorg Med Chem Lett20:755-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50481373 |
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n/a |
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Name | BDBM50481373 |
Synonyms: | CHEMBL593742 |
Type | Small organic molecule |
Emp. Form. | C27H29F8NO2 |
Mol. Mass. | 551.5119 |
SMILES | CC(C)CC[C@@H](N1CC[C@@H](CC(O)=O)C(F)(F)[C@H]1c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F |r| |
Structure |
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