Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50483275 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_700226 (CHEMBL1647327) |
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IC50 | 1406±n/a nM |
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Citation | Qin, J; Dhondi, P; Huang, X; Mandal, M; Zhao, Z; Pissarnitski, D; Zhou, W; Aslanian, R; Zhu, Z; Greenlee, W; Clader, J; Zhang, L; Cohen-Williams, M; Jones, N; Hyde, L; Palani, A Discovery of fused 5,6-bicyclic heterocycles as ?-secretase modulators. Bioorg Med Chem Lett21:664-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50483275 |
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n/a |
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Name | BDBM50483275 |
Synonyms: | CHEMBL1643431 |
Type | Small organic molecule |
Emp. Form. | C21H28N6O |
Mol. Mass. | 380.4866 |
SMILES | CCCCCN1CCCn2c1nnc2-c1ccc(c(OC)c1)-n1cnc(C)c1 |
Structure |
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